Īs an early disease, stage II CRC comprises approximately one-quarter of CRC. The features of LNs are increasingly being studied in CRC patients, including size of lymph nodes (SLNs), number of lymph nodes (NLNs), lymph nodes ratio and distribution of metastatic lymph nodes. The characteristics of lymph nodes (LNs) play an important role in the tumor staging system and are strongly correlated with the prognosis of CRC. Globally, colorectal cancer (CRC) is the third most common cancer and ranks second in mortality among all cancers, imposing a heavy burden on patients and society. Patients with SLNs > 5.8 mm and NLNs ≤ 22 are apt to have higher risk of recurrence. SLNs and NLNs are independent prognostic factors for patients with stage II CRC. The median follow-up time in the training cohort and the validation cohort were 60.8 months and 61.0 months respectively. In the validation cohort, Kaplan-Meier curves demonstrated SLNs (P = 0.0034) and NLNs (P = 0.0451) were positively correlated with RFS but not with OS. The cut-off values for SLNs and NLNs were 5.8 mm and 22, respectively, determined by the X-tile in the training cohort. Resultsĭata from 351 stage II CRC patients were analyzed.

Kaplan-Meier curves and Cox regression analyses were conducted for the two cohorts. The optimal cut-off values were obtained using X-tile program. MethodsĬonsecutive patients diagnosed with stage II CRC at Fudan University Shanghai Cancer Center (FUSCC) from January 2011 to December 2015 were reviewed, and 351 patients were randomly divided into two cohorts for cross-validation. The purpose of this study was to determine the prognostic role of the size of LNs (SLNs) measured by computer tomography (CT) and the number of retrieved LNs (NLNs) in the relapse-free survival (RFS) and overall survival (OS) among stage II CRC patients. Size and number of lymph nodes (LNs) were reported to be associated with the prognosis of stage II colorectal cancer (CRC).

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